TSEN54 Antikörper

Produktnummer ABIN7184298

Der Kaninchen Polyklonal Anti-TSEN54-Antikörper wurde für WB, IHC und ELISA validiert. Er ist geeignet, TSEN54 in Proben von Human zu detektieren.

Kurzübersicht für TSEN54 Antikörper (ABIN7184298)

Target: TSEN54 (tRNA Splicing Endonuclease 54 (TSEN54))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TSEN54 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-TSEN54 Antikörper

Kreuzreaktivität: Human

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from internal of Human TSEN54.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000, IHC:1:50-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TSEN54

Target: TSEN54 (tRNA Splicing Endonuclease 54 (TSEN54))

Andere Bezeichnung: TSEN54

Hintergrund:

Background: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.

Zody M.C., Nature 440:1045-1049(2006).
Paushkin S.V., Cell 117:311-321(2004).
Ota T., Nat. Genet. 36:40-45(2004).

Aliases: HsSen54 antibody, PCH2A antibody, PCH4 antibody, sen54 antibody, SEN54 homolog antibody, SEN54_HUMAN antibody, SEN54L antibody, tRNA-intron endonuclease SEN54 antibody, tRNA-splicing endonuclease subunit SEN54 antibody, Tsen54 antibody, TSEN54 tRNA splicing endonuclease subunit antibody

UniProt: Q7Z6J9

Pathways: Synaptic Membrane