SENP3 Antikörper

Produktnummer ABIN7184127

Der Kaninchen Polyklonal Anti-SENP3-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, SENP3 in Proben von Human zu detektieren.

Kurzübersicht für SENP3 Antikörper (ABIN7184127)

Target: SENP3 (SUMO/sentrin Specific Peptidase 3 (SENP3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SENP3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-SENP3 Antikörper

Kreuzreaktivität: Human, Maus

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from Internal of Human SENP3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000, IHC:1:50-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SENP3

Target: SENP3 (SUMO/sentrin Specific Peptidase 3 (SENP3))

Andere Bezeichnung: SENP3

Hintergrund:

Background: Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex, the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

Yeh E.T.H., Gene 248:1-14(2000).
Choi S.J., Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
Wiemann S., Genome Res. 11:422-435(2001).

Aliases: SENP3 antibody, SENP3_HUMAN antibody, Sentrin / SUMO specific protease 3 antibody, Sentrin specific protease 3 antibody, Sentrin-specific protease 3 antibody, Sentrin/SUMO-specific protease SENP3 antibody, SMT3IP1 antibody, SSP3 antibody, SUMO 1 specific protease 3 antibody, SUMO-1-specific protease 3 antibody, SUMO1 specific protease 3 antibody, SUMO1/sentrin/SMT3 specific peptidase 3 antibody, SUSP3 antibody

UniProt: Q9H4L4