POLR3B Antikörper

Produktnummer ABIN7184076

Der Kaninchen Polyklonal Anti-POLR3B-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, POLR3B in Proben von Human zu detektieren.

Kurzübersicht für POLR3B Antikörper (ABIN7184076)

Target: POLR3B (Polymerase (RNA) III (DNA Directed) Polypeptide B (POLR3B))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POLR3B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-POLR3B Antikörper

Kreuzreaktivität: Human, Maus

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from internal of Human RPC2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu POLR3B

Target: POLR3B (Polymerase (RNA) III (DNA Directed) Polypeptide B (POLR3B))

Andere Bezeichnung: POLR3B

Hintergrund:

Background: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft By similarity. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Hu P., Mol. Cell. Biol. 22:8044-8055(2002).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Ota T., Nat. Genet. 36:40-45(2004).

Aliases: C128 antibody, DNA directed RNA polymerase III 127.6 kDa polypeptide antibody, DNA directed RNA polymerase III subunit B antibody, DNA-directed RNA polymerase III 127.6 kDa polypeptide antibody, DNA-directed RNA polymerase III subunit B antibody, DNA-directed RNA polymerase III subunit RPC2 antibody, FLJ10388 antibody, polr3b antibody, Polymerase (RNA) III (DNA directed) polypeptide B antibody, RNA polymerase III subunit C2 antibody, RNA polymerase III subunit RPC2 antibody, RPC2 antibody, RPC2_HUMAN antibody

UniProt: Q9NW08