KSR2 Antikörper

Produktnummer ABIN7183716

Der Kaninchen Polyklonal Anti-KSR2-Antikörper wurde für ELISA, WB und IF validiert. Er ist geeignet, KSR2 in Proben von Human zu detektieren.

Kurzübersicht für KSR2 Antikörper (ABIN7183716)

Target: KSR2 (Kinase Suppressor of Ras 2 (KSR2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KSR2 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-KSR2 Antikörper

Kreuzreaktivität: Human, Maus

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from internal of Human KSR2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000, IF:1:100-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu KSR2

Target: KSR2 (Kinase Suppressor of Ras 2 (KSR2))

Andere Bezeichnung: KSR2

Hintergrund:

Background:

Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

Ota T., Nat. Genet. 36:40-45(2004).
Scherer S.E., Nature 440:346-351(2006).
Channavajhala P.L., J. Biol. Chem. 278:47089-47097(2003).

Aliases: FLJ25965 antibody, hKSR 2 antibody, hKSR2 antibody, Kinase suppressor of Ras 2 antibody, KSR 2 antibody, Ksr2 antibody, KSR2_HUMAN antibody

UniProt: Q6VAB6