beta Synuclein Antikörper

Produktnummer ABIN7182802

Dieser Anti-beta Synuclein-Antikörper ist ein Kaninchen-Polyklonal-Antikörper zum Nachweis von beta Synuclein in WB, ELISA, IHC und IF. Geeignet für Human.

Kurzübersicht für beta Synuclein Antikörper (ABIN7182802)

Target: beta Synuclein (SNCB) (Synuclein, beta (SNCB))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser beta Synuclein Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-beta Synuclein Antikörper

Verwendungszweck: SNCB Antibody

Kreuzreaktivität: Maus, Ratte

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from Human Synuclein beta antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu beta Synuclein

Target: beta Synuclein (SNCB) (Synuclein, beta (SNCB))

Andere Bezeichnung: SNCB

Hintergrund:

Background: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

Yuxin Fan, Hum. Mol. Genet., Oct 2006, 15: 3002 - 3011.
Makoto Hashimoto, J. Biol. Chem., May 2004, 279: 23622 - 23629.
Cristine Alves da Costa, J. Biol. Chem., Sep 2003, 278: 37330 - 37335.
Heather Snyder, J. Biol. Chem., Mar 2005, 280: 7562 - 7569.

Aliases: 14 kDa brain-specific protein antibody, Beta-synuclein antibody, Phosphoneuroprotein 14 antibody, PNP14 antibody, Sncb antibody, Synuclein beta antibody, SYUB_HUMAN antibody

UniProt: Q16143