CLNS1A Antikörper (C-Term)

Produktnummer ABIN7180144

Dieses Anti-CLNS1A-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CLNS1A in WB und ELISA. Geeignet für Human.

Kurzübersicht für CLNS1A Antikörper (C-Term) (ABIN7180144)

Target: CLNS1A (Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CLNS1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-CLNS1A Antikörper

Bindungsspezifität: C-Term

Kreuzreaktivität: Human

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from C-terminal of Human CLNS1A.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CLNS1A

Target: CLNS1A (Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A))

Andere Bezeichnung: CLNS1A

Hintergrund:

Background: Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.

Buyse G., Biochem. Biophys. Res. Commun. 218:822-827(1996).
Anquita J., Biochem. Biophys. Res. Commun. 208:89-95(1995).
Lamb F.S., Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.

Aliases: Chloride channel antibody, Chloride channel nucleotide sensitive 1A antibody, Chloride channel regulatory protein antibody, Chloride conductance regulator, volume sensitive antibody, Chloride conductance regulatory protein ICln antibody, Chloride ion current inducer protein antibody, ClCI antibody, CLNS 1A antibody, Clns1a antibody, CLNS1B antibody, I(Cln) antibody, ICln antibody, ICLN_HUMAN antibody, Methylosome subunit pICln antibody, nucleotide sensitive 1A antibody, Reticulocyte pICln antibody, Reticulocyte protein ICln antibody

UniProt: P54105

Pathways: Ribonucleoprotein Complex Subunit Organization