MSK2 Antikörper (Thr568)

Produktnummer ABIN7180050

Produktdetails anti-MSK2 Antikörper

Target: MSK2 (RPS6KA4) (Ribosomal Protein S6 Kinase A4 (RPS6KA4))

Bindungsspezifität: Thr568

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MSK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Human, Maus

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized non-phosphopeptide derived from Human MSK2 around the phosphorylation site of threonine 568 (M-Q-T(p)-P-C).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MSK2

Target: MSK2 (RPS6KA4) (Ribosomal Protein S6 Kinase A4 (RPS6KA4))

Andere Bezeichnung: RPS6KA4 (RPS6KA4 Produkte)

Synonyme: MSK2 antikoerper, RSK-B antikoerper, 1110069D02Rik antikoerper, 90kDa antikoerper, AI848992 antikoerper, Msk2 antikoerper, mMSK2 antikoerper, ribosomal protein S6 kinase A4 antikoerper, ribosomal protein S6 kinase, polypeptide 4 antikoerper, RPS6KA4 antikoerper, Rps6ka4 antikoerper

Hintergrund:

Background: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.

Pierrat B.,J. Biol. Chem. 273:29661-29671(1998).
Deak M.,EMBO J. 17:4426-4441(1998).
Soloaga A.,EMBO J. 22:2788-2797(2003).

Aliases: 90 kDa ribosomal protein S6 kinase 4 antibody, EC 2.7.11.1 antibody, KS6A4_HUMAN antibody, Mitogen and stress activated protein kinase 2 antibody, Nuclear mitogen and stress activated protein kinase 2 antibody, Nuclear mitogen- and stress-activated protein kinase 2 antibody, Ribosomal protein kinase B antibody, Ribosomal protein S6 kinase 90kD polypeptide 4 antibody, Ribosomal protein S6 kinase 90 kDa polypeptide 4 antibody, Ribosomal protein S6 kinase alpha 4 antibody, Ribosomal protein S6 kinase alpha-4 antibody, RPS6KA4 antibody, RSKB antibody, S6K-alpha-4 antibody

UniProt: O75676