Claudin 1 Antikörper (Tyr210)

Produktnummer ABIN7179992

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Claudin 1 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Claudin 1 Antikörper (Tyr210) (ABIN7179992)

Target: Claudin 1 (CLDN1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Claudin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Claudin 1 Antikörper

Bindungsspezifität: Tyr210

Kreuzreaktivität: Human, Maus

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized non-phosphopeptide derived from Human Claudin 1 around the phosphorylation site of tyrosine 210 (G-K-D-Y(p)-V).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Claudin 1

Target: Claudin 1 (CLDN1)

Andere Bezeichnung: CLDN1

Hintergrund:

Background: Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (). CLDN1 acts as a coreceptor for HCV entry into hepatic cells.

Swisshelm K.L., Gene 226:285-295(1999).
Halford S., Cytogenet. Cell Genet. 88:217-217(2000).
Kraemer F., Hum. Genet. 107:249-256(2000).

Aliases: Claudin-1 antibody, Claudin1 antibody, CLD 1 antibody, CLD1 antibody, CLD1_HUMAN antibody, CLDN 1 antibody, Cldn1 antibody, ILVASC antibody, SEMP 1 antibody, SEMP1 antibody, Senescence associated epithelial membrane protein 1 antibody, Senescence associated epithelial membrane protein antibody, Senescence-associated epithelial membrane protein antibody

UniProt: O95832

Pathways: Cell-Cell Junction Organization, Hepatitis C