Vpx Protein (VPX) (AA 1-112) Antikörper
Kurzübersicht für Vpx Protein (VPX) (AA 1-112) Antikörper (ABIN7179346)
Target
Alle Vpx Protein (VPX) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 1-112
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Kreuzreaktivität
- Simian Immunodeficiency Virus (SIV)
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Aufreinigung
- >95%, Protein G purified
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Immunogen
- Recombinant Simian immunodeficiency virus Protein Vpx protein (1-112AA)
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Isotyp
- IgG
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anti-Vpx Protein (VPX) (AA 1-112), (subtype A) antibody
VPX Reaktivität: Human Immunodeficiency Virus (HIV) ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C,-80 °C
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Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Vpx Protein (VPX)
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Andere Bezeichnung
- vpx
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Substanzklasse
- Viral Protein
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Hintergrund
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Background: Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.
Aliases: vpx antibody, Protein Vpx antibody, Viral protein X antibody, X ORF protein antibody
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UniProt
- P11266
Target
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