Kobra Venom Factor,CVF (AA 733-984) Antikörper (Biotin)

Produktnummer ABIN7178125

Produktdetails

Target: Cobra Venom Factor,CVF

Bindungsspezifität: AA 733-984

Reaktivität: Kobra

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Biotin

Applikation: ELISA

Kreuzreaktivität: Kobra

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Naja kaouthia Cobra venom factor protein (733-984AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Antigendetails

Target: Cobra Venom Factor,CVF

Andere Bezeichnung: Cobra venom factor

Hintergrund:

Background: Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity.

Aliases: antibody, Cobra venom factor antibody, CVF antibody, CVFk antibody, Complement C3 homolog) [Cleaved into: Cobra venom factor alpha chain, Cobra venom factor gamma chain, Cobra venom factor beta chain] antibody

UniProt: Q91132