KEAP1 Antikörper (AA 1-624)
Kurzübersicht für KEAP1 Antikörper (AA 1-624) (ABIN7177369)
Target
Alle KEAP1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
 - AA 1-624
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Kreuzreaktivität
 - Human, Maus
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Aufreinigung
 - >95%, Protein G purified
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Immunogen
 - Recombinant Mouse Kelch-like ECH-associated protein 1 protein (1-624AA)
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Isotyp
 - IgG
 
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Applikationshinweise
 - Recommended dilution: WB:1:500-1:2000,
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Beschränkungen
 - Nur für Forschungszwecke einsetzbar
 
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Format
 - Liquid
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Buffer
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                        Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 
                                            
Konservierungsmittel
 - ProClin
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Vorsichtsmaßnahmen
 - This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
 - -20 °C,-80 °C
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Informationen zur Lagerung
 - Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
 
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- KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
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Andere Bezeichnung
 - Keap1
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Hintergrund
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Background: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).
Aliases: Keap1 antibody, Inrf2 antibody, Kiaa0132Kelch-like ECH-associated protein 1 antibody, Cytosolic inhibitor of Nrf2 antibody, INrf2 antibody
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UniProt
 - Q9Z2X8
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Pathways
 - Maintenance of Protein Location
 
Target
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