TRIM21 Antikörper (AA 1-470)

Produktnummer ABIN7177161

Der Kaninchen Polyklonal Anti-TRIM21-Antikörper wurde für ELISA validiert. Er ist geeignet, TRIM21 in Proben von Maus zu detektieren.

Kurzübersicht für TRIM21 Antikörper (AA 1-470) (ABIN7177161)

Target: TRIM21 (Tripartite Motif Containing 21 (TRIM21))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIM21 Antikörper ist unkonjugiert

Applikation: ELISA

Produktdetails anti-TRIM21 Antikörper

Bindungsspezifität: AA 1-470

Kreuzreaktivität: Maus

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Mouse E3 ubiquitin-protein ligase TRIM21 protein (1-470AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TRIM21

Target: TRIM21 (Tripartite Motif Containing 21 (TRIM21))

Andere Bezeichnung: Trim21

Hintergrund:

Background: E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B (\'Thr-187\' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2.

Aliases: Trim21 antibody, Ro52 antibody, Ssa1 antibody, E3 ubiquitin-protein ligase TRIM21 antibody, EC 2.3.2.27 antibody, 52 kDa Ro protein antibody, 52 kDa ribonucleoprotein autoantigen Ro/SS-A antibody, RING-type E3 ubiquitin transferase TRIM21 antibody, Ro(SS-A) antibody, Sjoegren syndrome type A antigen antibody, SS-A antibody, Tripartite motif-containing protein 21 antibody

UniProt: Q62191