SLUG Antikörper (AA 12-124) (HRP)

Produktnummer ABIN7176607

Dieses Anti-SLUG-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SLUG in ELISA. Geeignet für Human.

Kurzübersicht für SLUG Antikörper (AA 12-124) (HRP) (ABIN7176607)

Target: SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLUG Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-SLUG Antikörper (HRP)

Bindungsspezifität: AA 12-124

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Zinc finger protein SNAI2 protein (12-124AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SLUG

Target: SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))

Andere Bezeichnung: SNAI2

Hintergrund:

Background: Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.

Aliases: MGC10182 antibody, Neural crest transcription factor Slug antibody, Protein snail homolog 2 antibody, Slug (chicken homolog) zinc finger protein antibody, Slug homolog zinc finger protein antibody, Slug zinc finger protein antibody, SLUGH antibody, SLUGH 1 antibody, SLUGH1 antibody, SNAI 2 antibody, Snai2 antibody, SNAI2_HUMAN antibody, Snail 2 antibody, Snail homolog 2 antibody, Snail2 antibody, WS 2D antibody, WS2D antibody, Zinc finger protein SLUG antibody, Zinc finger protein SNAI2 antibody

UniProt: O43623