UBE2K Antikörper (AA 2-200)

Produktnummer ABIN7174460

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch UBE2K in ELISA, IHC und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für UBE2K Antikörper (AA 2-200) (ABIN7174460)

Target: UBE2K (Ubiquitin-Conjugating Enzyme E2K (UBE2K))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBE2K Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-UBE2K Antikörper

Bindungsspezifität: AA 2-200

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Ubiquitin-conjugating enzyme E2 K protein (2-200AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:10-1:100, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu UBE2K

Target: UBE2K (Ubiquitin-Conjugating Enzyme E2K (UBE2K))

Andere Bezeichnung: UBE2K

Hintergrund:

Background: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of \\\'Lys-48\\\'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B, in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.

Aliases: E2 25K antibody, E2(25K) antibody, HIP-2 antibody, Huntingtin interacting protein 2 antibody, Huntingtin-interacting protein 2 antibody, HYPG antibody, LIG antibody, UBC1 antibody, UBE2K antibody, UBE2K_HUMAN antibody, Ubiquitin carrier protein antibody, Ubiquitin conjugating enzyme E2 25 kDa antibody, ubiquitin conjugating enzyme E2K antibody, ubiquitin conjugating enzyme E2K (UBC1 homolog, yeast) antibody, Ubiquitin protein ligase antibody, Ubiquitin-conjugating enzyme E2 K antibody, Ubiquitin-conjugating enzyme E2(25K) antibody, Ubiquitin-conjugating enzyme E2-25 kDa antibody, Ubiquitin-conjugating enzyme E2-25K antibody, Ubiquitin-protein ligase antibody

UniProt: P61086