USP3 Antikörper (C-Term)

Produktnummer ABIN7174308

Der Kaninchen Polyklonal Anti-USP3-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, USP3 in Proben von Human zu detektieren.

Kurzübersicht für USP3 Antikörper (C-Term) (ABIN7174308)

Target: USP3 (Ubiquitin Specific Peptidase 3 (USP3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-USP3 Antikörper

Bindungsspezifität: AA 101-400, C-Term

Kreuzreaktivität: Human, Maus

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Ubiquitin carboxyl-terminal hydrolase 30 protein (101-400AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu USP3

Target: USP3 (Ubiquitin Specific Peptidase 3 (USP3))

Andere Bezeichnung: USP3

Hintergrund:

Background: Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PARK2): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin\\\'s ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves \\\'Lys-6\\\'- and \\\'Lys-11\\\'-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at \\\'Ser-65\\\' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).

Aliases: Deubiquitinating enzyme 30 antibody, FLJ40511 antibody, Ub-specific protease 30 antibody, Ubiquitin carboxyl terminal hydrolase 30 antibody, Ubiquitin carboxyl-terminal hydrolase 30 antibody, Ubiquitin specific peptidase 30 antibody, Ubiquitin specific processing protease 30 antibody, Ubiquitin thioesterase 30 antibody, Ubiquitin thiolesterase 30 antibody, Ubiquitin-specific-processing protease 30 antibody, UBP30_HUMAN antibody, usp30 antibody

UniProt: Q70CQ3