USP28 Antikörper (AA 430-580)

Produktnummer ABIN7174303

Dieses Anti-USP28-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von USP28 in WB, ELISA und IHC. Geeignet für Human.

Kurzübersicht für USP28 Antikörper (AA 430-580) (ABIN7174303)

Target: USP28 (Ubiquitin Specific Peptidase 28 (USP28))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP28 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-USP28 Antikörper

Bindungsspezifität: AA 430-580

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Ubiquitin carboxyl-terminal hydrolase 28 protein (430-580AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu USP28

Target: USP28 (Ubiquitin Specific Peptidase 28 (USP28))

Andere Bezeichnung: USP28

Hintergrund:

Background: Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306).

Aliases: Deubiquitinating enzyme 28 antibody, KIAA1515 antibody, Ubiquitin carboxyl terminal hydrolase 28 antibody, Ubiquitin carboxyl-terminal hydrolase 28 antibody, ubiquitin carboxyl-terminal hydrolase 28 variant 1 antibody, Ubiquitin specific peptidase 28 antibody, Ubiquitin specific processing protease 28 antibody, Ubiquitin specific protease 28 antibody, Ubiquitin thioesterase 28 antibody, Ubiquitin thiolesterase 28 antibody, Ubiquitin-specific-processing protease 28 antibody, UBP28_HUMAN antibody, USP 28 antibody, USP28 antibody, USP28 protein antibody

UniProt: Q96RU2