YES1 Antikörper (AA 1-155)

Produktnummer ABIN7174080

Der Kaninchen Polyklonal Anti-YES1-Antikörper wurde für WB, ELISA, IHC und IF validiert. Er ist geeignet, YES1 in Proben von Human zu detektieren.

Kurzübersicht für YES1 Antikörper (AA 1-155) (ABIN7174080)

Target: YES1 (V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser YES1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-YES1 Antikörper

Bindungsspezifität: AA 1-155

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Tyrosine-protein kinase Yes protein (1-155AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu YES1

Target: YES1 (V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1))

Andere Bezeichnung: YES1

Hintergrund:

Background: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.

Aliases: c Yes antibody, Cellular Yes 1 protein antibody, Cellular Yes1 protein antibody, HsT441 antibody, P61 YES antibody, p61-Yes antibody, Proto oncogene tyrosine protein kinase YES antibody, Proto-oncogene c-Yes antibody, Tyrosine-protein kinase Yes antibody, v yes 1 Yamaguchi sarcoma viral oncogene homolog 1 antibody, Viral oncogene yes 1 homolog 1 antibody, Viral oncogene yes1 homolog 1 antibody, Yamaguchi sarcoma oncogene antibody, Yes 1 antibody, Yes antibody, YES proto oncogene 1, Src family tyrosine kinase antibody, YES_HUMAN antibody, YES1 antibody, YES1 proto oncogene, Src family tyrosine kinase antibody

UniProt: P07947

Pathways: CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling