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TSEN2 Antikörper (AA 1-220)

Dieses Anti-TSEN2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TSEN2 in WB, ELISA und IHC. Geeignet für Human.
Produktnummer ABIN7173541

Kurzübersicht für TSEN2 Antikörper (AA 1-220) (ABIN7173541)

Target

Alle TSEN2 Antikörper anzeigen
TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))

Reaktivität

  • 31
  • 16
  • 16
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 29
  • 2
Kaninchen

Klonalität

  • 31
Polyklonal

Konjugat

  • 12
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser TSEN2 Antikörper ist unkonjugiert

Applikation

  • 31
  • 13
  • 9
  • 3
  • 3
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 9
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 1-220

    Kreuzreaktivität

    Human

    Aufreinigung

    Antigen Affinity Purified

    Immunogen

    Recombinant Human tRNA-splicing endonuclease subunit Sen2 protein (1-220AA)

    Isotyp

    IgG
  • Applikationshinweise

    Recommended dilution: WB:1:200-1:1000, IHC:1:50-1:200,

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))

    Andere Bezeichnung

    TSEN2

    Hintergrund

    Background: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5\\\'- and 3\\\'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2\\\',3\\\'-cyclic phosphate and 5\\\'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5\\\'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3\\\'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3\\\'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.

    Aliases: HsSen2 antibody, MGC2776 antibody, MGC4440 antibody, SEN2 antibody, SEN2_HUMAN antibody, SEN2L antibody, tRNA intron endonuclease Sen2 antibody, tRNA splicing endonuclease 2 homolog (SEN2, S. cerevisiae) antibody, tRNA splicing endonuclease subunit Sen2 antibody, tRNA-intron endonuclease sen2 antibody, tRNA-splicing endonuclease subunit Sen2 antibody, TSEN 2 antibody, TSEN2 antibody

    UniProt

    Q8NCE0

    Pathways

    Nuclear Receptor Transcription Pathway, Regulation of Lipid Metabolism by PPARalpha
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