TRIB3 Antikörper (AA 152-325) (Biotin)

Produktnummer ABIN7173366

Der Kaninchen Polyklonal Anti-TRIB3-Antikörper wurde für ELISA validiert. Er ist geeignet, TRIB3 in Proben von Human zu detektieren.

Kurzübersicht für TRIB3 Antikörper (AA 152-325) (Biotin) (ABIN7173366)

Target: TRIB3 (Tribbles Homolog 3 (Drosophila) (TRIB3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIB3 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-TRIB3 Antikörper (Biotin)

Bindungsspezifität: AA 152-325

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Tribbles homolog 3 protein (152-325AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TRIB3

Target: TRIB3 (Tribbles Homolog 3 (Drosophila) (TRIB3))

Andere Bezeichnung: TRIB3

Hintergrund:

Background: Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the \\\'Thr-308\\\' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA.

Aliases: C20orf97 antibody, Neuronal cell death inducible putative kinase antibody, Neuronal cell death-inducible putative kinase antibody, NIPK antibody, p65 interacting inhibitor of NF-kappaB antibody, p65-interacting inhibitor of NF-kappa-B antibody, SINK antibody, SKIP 3 antibody, SKIP3 antibody, TRB 3 antibody, TRB-3 antibody, TRB3 antibody, TRIB 3 antibody, Trib3 antibody, TRIB3_HUMAN antibody, Tribbles homolog 3 antibody, Tribbles pseudokinase 3 antibody, Tribbles3 antibody

UniProt: Q96RU7

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Lipid Metabolism by PPARalpha