TMEM59 Antikörper (AA 59-201)
Kurzübersicht für TMEM59 Antikörper (AA 59-201) (ABIN7173245)
Target
Alle TMEM59 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Bindungsspezifität
- AA 59-201
-
Kreuzreaktivität
- Human
-
Aufreinigung
- >95%, Protein G purified
-
Immunogen
- Recombinant Human Transmembrane protein 59 protein (59-201AA)
-
Isotyp
- IgG
-
-
-
-
Applikationshinweise
- Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200,
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Liquid
-
Buffer
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
Konservierungsmittel
- ProClin
-
Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Lagerung
- -20 °C,-80 °C
-
Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
-
- TMEM59 (Transmembrane Protein 59 (TMEM59))
-
Andere Bezeichnung
- TMEM59
-
Hintergrund
-
Background: Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:27273576, PubMed:23376921). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278).
Aliases: C1orf8 antibody, HSPC001 antibody, Liver membrane-bound protein antibody, TMEM59 antibody, TMEM59 transmembrane protein 59 antibody, TMM59_HUMAN antibody, Transmembrane protein 59 antibody
-
UniProt
- Q9BXS4
Target
-