TMED1 Antikörper (AA 35-190)

Produktnummer ABIN7172974

Dieses Anti-TMED1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TMED1 in WB, ELISA und IHC. Geeignet für Human.

Kurzübersicht für TMED1 Antikörper (AA 35-190) (ABIN7172974)

Target: TMED1 (Transmembrane Emp24 Protein Transport Domain Containing 1 (TMED1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TMED1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-TMED1 Antikörper

Bindungsspezifität: AA 35-190

Kreuzreaktivität: Human, Maus

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Transmembrane emp24 domain-containing protein 10 protein (35-190AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TMED1

Target: TMED1 (Transmembrane Emp24 Protein Transport Domain Containing 1 (TMED1))

Andere Bezeichnung: TMED1

Hintergrund:

Background: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor, the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus.

Aliases: 1110014C03Rik antibody, 21 kDa transmembrane trafficking protein antibody, 21 kDa transmembrane-trafficking protein antibody, MGC102351 antibody, p23 antibody, p24 family protein delta 1 antibody, p24 family protein delta-1 antibody, p24(DELTA) antibody, p24delta antibody, p24delta1 antibody, S31I125 antibody, S31III125 antibody, TMED 10 antibody, Tmed10 antibody, TMEDA_HUMAN antibody, Tmp 21 I antibody, Tmp 21 antibody, Tmp 21 I antibody, Tmp-21-I antibody, Transmembrane emp24 domain containing protein 10 antibody, Transmembrane emp24 domain-containing protein 10 antibody, Transmembrane emp24-like trafficking protein 10 (yeast) antibody, Transmembrane protein Tmp21 antibody, Transmembrane trafficking protein 21kD antibody

UniProt: P49755