THOC1 Antikörper (AA 428-657)

Produktnummer ABIN7172050

Produktdetails anti-THOC1 Antikörper

Target: THOC1 (THO Complex 1 (THOC1))

Bindungsspezifität: AA 428-657

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser THOC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Chromatin Immunoprecipitation (ChIP)

Kreuzreaktivität: Human, Maus

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human THO complex subunit 1 protein (428-657AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu THOC1

Target: THOC1 (THO Complex 1 (THOC1))

Andere Bezeichnung: THOC1 (THOC1 Produkte)

Synonyme: p84 antikoerper, MGC114861 antikoerper, Tho1 antikoerper, THOC1 antikoerper, Hpr1 antikoerper, HPR1 antikoerper, P84 antikoerper, P84N5 antikoerper, 3110002N20Rik antikoerper, AW107452 antikoerper, NMP-84 antikoerper, LRRGT00070 antikoerper, THO complex 1 antikoerper, THO complex 1 protein L homeolog antikoerper, THO complex subunit 1 antikoerper, THO complex 1 protein antikoerper, thoc1 antikoerper, thoc1.L antikoerper, THOC1 antikoerper, LOC100123388 antikoerper, Thoc1 antikoerper

Hintergrund:

Background: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5\\\' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi\\\'s sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation. Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.

Aliases: hTREX84 antibody, Death domain containing protein p84N5 antibody, HPR 1 antibody, HPR1 antibody, hTREX84 antibody, Nuclear matrix protein p84 antibody, P84 antibody, p84N5 antibody, Tho 1 antibody, THO complex 1 antibody, THO complex subunit 1 antibody, Tho1 antibody, THOC 1 antibody, Thoc1 antibody, THOC1_HUMAN antibody

UniProt: Q96FV9