TSPAN12 Antikörper (AA 111-224)

Produktnummer ABIN7171846

Dieses Anti-TSPAN12-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TSPAN12 in ELISA, IHC und IF. Geeignet für Human.

Kurzübersicht für TSPAN12 Antikörper (AA 111-224) (ABIN7171846)

Target: TSPAN12 (Tetraspanin 12 (TSPAN12))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TSPAN12 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-TSPAN12 Antikörper

Bindungsspezifität: AA 111-224

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Tetraspanin-12 protein (111-224AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TSPAN12

Target: TSPAN12 (Tetraspanin 12 (TSPAN12))

Andere Bezeichnung: TSPAN12

Hintergrund:

Background: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.

Aliases: TSPAN12 antibody, NET2 antibody, TM4SF12 antibody, UNQ774/PRO1568Tetraspanin-12 antibody, Tspan-12 antibody, Tetraspan NET-2 antibody, Transmembrane 4 superfamily member 12 antibody

UniProt: O95859