TNKS2 Antikörper (AA 1-246)

Produktnummer ABIN7171500

Der Kaninchen-Polyklonal Anti-TNKS2-Antikörper wurde für ELISA, IHC und IF validiert. Er ist geeignet zum Nachweis von TNKS2 in Proben aus Human. }

Kurzübersicht für TNKS2 Antikörper (AA 1-246) (ABIN7171500)

Target: TNKS2 (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNKS2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-TNKS2 Antikörper

Bindungsspezifität: AA 1-246

Verwendungszweck: TNKS2 Antibody

Aufreinigung: Protein G purified

Reinheit: >95 %

Immunogen: Recombinant Human Tankyrase-2 protein (1-246AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TNKS2

Target: TNKS2 (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2))

Andere Bezeichnung: TNKS2

Hintergrund:

Background: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity.

Aliases: ADP-ribosyltransferase diphtheria toxin-like 6 antibody, ARTD6 antibody, PARP 5b antibody, PARP 5c antibody, PARP-5b antibody, PARP-5c antibody, PARP5B antibody, PARP5C antibody, pART6 antibody, Poly [ADP ribose] polymerase 5B antibody, Poly [ADP-ribose] polymerase 5B antibody, TANK2 antibody, Tankyrase 2 antibody, Tankyrase II antibody, Tankyrase like protein antibody, Tankyrase related protein antibody, Tankyrase TRF1 interacting ankyrin related ADP ribose polymerase 2 antibody, Tankyrase-2 antibody, Tankyrase-like protein antibody, Tankyrase-related protein antibody, TNKL antibody, TNKS 2 antibody, TNKS-2 antibody, TNKS2 antibody, TNKS2_HUMAN antibody, TRF1 Interacting Ankyrin Related ADP ribose polymerase 2 antibody, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 antibody

UniProt: Q9H2K2