SDCBP Antikörper (AA 21-228) (FITC)

Produktnummer ABIN7171275

Der Kaninchen Polyklonal Anti-SDCBP-Antikörper wurde für validiert. Er ist geeignet, SDCBP in Proben von Human zu detektieren.

Kurzübersicht für SDCBP Antikörper (AA 21-228) (FITC) (ABIN7171275)

Target: SDCBP (Syndecan Binding Protein (Syntenin) (SDCBP))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SDCBP Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Produktdetails anti-SDCBP Antikörper (FITC)

Bindungsspezifität: AA 21-228

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Syntenin-1 protein (21-228AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SDCBP

Target: SDCBP (Syndecan Binding Protein (Syntenin) (SDCBP))

Andere Bezeichnung: SDCBP

Hintergrund:

Background: Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).

Aliases: MDA-9 antibody, MDA9 antibody, Melanoma differentiation-associated protein 9 antibody, Pro-TGF-alpha cytoplasmic domain-interacting protein 18 antibody, Scaffold protein Pbp1 antibody, SDCB1_HUMAN antibody, SDCBP antibody, ST1 antibody, SYCL antibody, Syndecan binding protein (syntenin) antibody, Syndecan binding protein 1 antibody, Syndecan-binding protein 1 antibody, Syntenin 1 antibody, Syntenin-1 antibody, TACIP18 antibody

UniProt: O00560