SMARCD1 Antikörper (AA 7-124) (Biotin)

Produktnummer ABIN7171072

Produktdetails anti-SMARCD1 Antikörper (Biotin)

Target: SMARCD1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily D, Member 1 (SMARCD1))

Bindungsspezifität: AA 7-124

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMARCD1 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 protein (7-124AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SMARCD1

Target: SMARCD1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily D, Member 1 (SMARCD1))

Andere Bezeichnung: SMARCD1 (SMARCD1 Produkte)

Hintergrund:

Background: Involved in chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation.

Aliases: 60 kDa BRG-1/Brm-associated factor subunit A antibody, 60 kDa BRG1/Brm associated factor subunit A antibody, BAF60A antibody, BRG1 associated factor 60A antibody, BRG1-associated factor 60A antibody, Chromatin remodeling complex BAF60A subunit antibody, CRACD1 antibody, Mammalian chromatin remodeling complex BRG1 associated factor 60A antibody, Rsc6p antibody, SMARCD1 antibody, SMRD1 antibody, SMRD1_HUMAN antibody, SWI/SNF complex 60 kDa subunit A antibody, SWI/SNF complex 60 kDa subunit antibody, SWI/SNF related matrix associated actin dependent regulator of chromatin d1 antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 antibody, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 antibody, Swp73 like protein antibody

UniProt: Q96GM5