SUN2 Antikörper (AA 45-155)

Produktnummer ABIN7170975

Der Kaninchen Polyklonal Anti-SUN2-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, SUN2 in Proben von Human zu detektieren.

Kurzübersicht für SUN2 Antikörper (AA 45-155) (ABIN7170975)

Target: SUN2 (Sad1 and UNC84 Domain Containing 2 (SUN2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SUN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-SUN2 Antikörper

Bindungsspezifität: AA 45-155

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human SUN domain-containing protein 2 protein (45-155AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SUN2

Target: SUN2 (Sad1 and UNC84 Domain Containing 2 (SUN2))

Andere Bezeichnung: SUN2

Hintergrund:

Background: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins, SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis, SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.

Aliases: SUN2 antibody, FRIGG antibody, KIAA0668 antibody, RAB5IP antibody, UNC84B antibody, SUN domain-containing protein 2 antibody, Protein unc-84 homolog B antibody, Rab5-interacting protein antibody, Rab5IP antibody, Sad1/unc-84 protein-like 2 antibody

UniProt: Q9UH99

Pathways: Maintenance of Protein Location, SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion