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SMC5 Antikörper (AA 296-403)

Der Kaninchen Polyklonal Anti-SMC5-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, SMC5 in Proben von Human zu detektieren.
Produktnummer ABIN7170870

Kurzübersicht für SMC5 Antikörper (AA 296-403) (ABIN7170870)

Target

Alle SMC5 Antikörper anzeigen
SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))

Reaktivität

  • 36
  • 19
  • 12
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 34
  • 1
  • 1
Kaninchen

Klonalität

  • 36
Polyklonal

Konjugat

  • 11
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser SMC5 Antikörper ist unkonjugiert

Applikation

  • 24
  • 13
  • 13
  • 12
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
Western Blotting (WB), ELISA
  • Bindungsspezifität

    • 15
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    AA 296-403

    Kreuzreaktivität

    Human

    Aufreinigung

    >95%, Protein G purified

    Immunogen

    Recombinant Human Structural maintenance of chromosomes protein 5 protein (296-403AA)

    Isotyp

    IgG
  • Applikationshinweise

    Recommended dilution: WB:1:500-1:5000,

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))

    Andere Bezeichnung

    SMC5

    Hintergrund

    Background: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression, the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).

    Aliases: SMC5 antibody, KIAA0594 antibody, SMC5L1 antibody, Structural maintenance of chromosomes protein 5 antibody, SMC protein 5 antibody, SMC-5 antibody, hSMC5 antibody

    UniProt

    Q8IY18
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