ESRRB Antikörper (AA 432-502) (HRP)

Produktnummer ABIN7170765

Produktdetails anti-ESRRB Antikörper (HRP)

Target: ESRRB (Estrogen-Related Receptor beta (ESRRB))

Bindungsspezifität: AA 432-502

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ESRRB Antikörper ist konjugiert mit HRP

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Steroid hormone receptor ERR2 protein (432-502AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ESRRB

Target: ESRRB (Estrogen-Related Receptor beta (ESRRB))

Andere Bezeichnung: ESRRB (ESRRB Produkte)

Hintergrund:

Background: Isoform 3: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5\'TCAAGGTCA-3\' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity (PubMed:17920186, PubMed:19755138). Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (By similarity). Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 (PubMed:23836911). Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (PubMed:17920186, PubMed:19755138). During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (By similarity).

Aliases: Err 2 antibody, ERR b antibody, ERR B2 antibody, ERR beta 2 antibody, ERR beta antibody, ERR beta-2 antibody, ERR-beta antibody, Err2 antibody, ERR2_HUMAN antibody, ERRB 2 antibody, ERRb antibody, ERRB2 antibody, ERRbeta 2 antibody, ERRbeta antibody, ESR L2 antibody, ESRL 2 antibody, ESRL2 antibody, Esrrb antibody, Estrogen receptor like 2 antibody, Estrogen receptor related 2 antibody, Estrogen receptor-like 2 antibody, Estrogen-related receptor beta antibody, Estrrb antibody, Nr3b2 antibody, Nuclear receptor ERRB2 antibody, Nuclear receptor subfamily 3 group B member 2 antibody, Orphan nuclear receptor antibody, Steroid hormone receptor ERR 2 antibody, Steroid hormone receptor ERR2 antibody

UniProt: O95718

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Stem Cell Maintenance