Spindlin 1 Antikörper (AA 1-262)

Produktnummer ABIN7170599

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Spindlin 1 in WB, IHC und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Spindlin 1 Antikörper (AA 1-262) (ABIN7170599)

Target: Spindlin 1 (SPIN1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Spindlin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-Spindlin 1 Antikörper

Bindungsspezifität: AA 1-262

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Spindlin-1 protein (1-262AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Spindlin 1

Target: Spindlin 1 (SPIN1)

Andere Bezeichnung: SPIN1

Hintergrund:

Background: Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at \\\'Lys-4\\\' and asymmetrically dimethylated at \\\'Arg-8\\\' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.

Aliases: OCR antibody, Ovarian cancer-related protein antibody, SPIN antibody, Spin1 antibody, SPIN1_HUMAN antibody, Spindlin-1 antibody

UniProt: Q9Y657