SNX27 Antikörper (AA 458-497)

Produktnummer ABIN7170381

Der Kaninchen Polyklonal Anti-SNX27-Antikörper wurde für ELISA, WB und IHC validiert. Er ist geeignet, SNX27 in Proben von Human zu detektieren.

Kurzübersicht für SNX27 Antikörper (AA 458-497) (ABIN7170381)

Target: SNX27 (Sorting Nexin 27 (SNX27))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNX27 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-SNX27 Antikörper

Bindungsspezifität: AA 458-497

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Sorting nexin-27 protein (458-497AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SNX27

Target: SNX27 (Sorting Nexin 27 (SNX27))

Andere Bezeichnung: SNX27

Hintergrund:

Background: Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.

Aliases: KIAA0488 antibody, Methamphetamine responsive transcript 1 antibody, MGC126871 antibody, MGC126873 antibody, MGC20471 antibody, MRT1 antibody, MY014 antibody, OTTHUMP00000042487 antibody, RP11-98D18.12 antibody, SNX27 antibody, SNX27_HUMAN antibody, Sorting nexin family member 27 antibody, Sorting nexin-27 antibody

UniProt: Q96L92