Sortilin 1 Antikörper (AA 328-457) (HRP)

Produktnummer ABIN7170338

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Sortilin 1 in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Sortilin 1 Antikörper (AA 328-457) (HRP) (ABIN7170338)

Target: Sortilin 1 (SORT1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Sortilin 1 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-Sortilin 1 Antikörper (HRP)

Bindungsspezifität: AA 328-457

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Sortilin protein (328-457AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Sortilin 1

Target: Sortilin 1 (SORT1)

Andere Bezeichnung: SORT1

Hintergrund:

Background: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.

Aliases: 100 kDa NT receptor antibody, Glycoprotein 95 antibody, Gp 95 antibody, Gp95 antibody, LDLCQ6 antibody, Neurotensin receptor 3 antibody, NT 3 antibody, NT3 antibody, NTR 3 antibody, NTR3 antibody, OTTHUMP00000013784 antibody, SORT 1 antibody, SORT_HUMAN antibody, SORT1 (gene name) antibody, Sort1 antibody, Sortilin 1 antibody, Sortilin antibody

UniProt: Q99523

Pathways: Neurotrophin Signalübertragung