SLC26A6 Antikörper (AA 554-668) (HRP)

Produktnummer ABIN7170214

Dieses Anti-SLC26A6-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SLC26A6 in ELISA. Geeignet für Human.

Kurzübersicht für SLC26A6 Antikörper (AA 554-668) (HRP) (ABIN7170214)

Target: SLC26A6 (Solute Carrier Family 26, Member 6 (SLC26A6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLC26A6 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-SLC26A6 Antikörper (HRP)

Bindungsspezifität: AA 554-668

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Solute carrier family 26 member 6 protein (554-668AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SLC26A6

Target: SLC26A6 (Solute Carrier Family 26, Member 6 (SLC26A6))

Andere Bezeichnung: SLC26A6

Hintergrund:

Background: Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH .

Aliases: Anion exchange transporter antibody, Anion transporter 1 antibody, DKFZp586E1422 antibody, Pendrin L1 antibody, Pendrin like protein 1 antibody, Pendrin-L1 antibody, Pendrin-like protein 1 antibody, S26A6_HUMAN antibody, SLC26A6 antibody, Solute carrier family 26 member 6 antibody, Sulfate anion transporter antibody

UniProt: Q9BXS9

Pathways: Dicarboxylic Acid Transport