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SPPL2A Antikörper (AA 26-172)

SPPL2A Reaktivität: Human ELISA, WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7169623
  • Target Alle SPPL2A Antikörper anzeigen
    SPPL2A (Signal Peptide Peptidase-Like 2A (SPPL2A))
    Bindungsspezifität
    • 7
    • 4
    • 2
    • 2
    • 1
    AA 26-172
    Reaktivität
    • 16
    • 1
    • 1
    Human
    Wirt
    • 14
    • 2
    Kaninchen
    Klonalität
    • 15
    • 1
    Polyklonal
    Konjugat
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    Dieser SPPL2A Antikörper ist unkonjugiert
    Applikation
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Kreuzreaktivität
    Human
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human Signal peptide peptidase-like 2A protein (26-172AA)
    Isotyp
    IgG
  • Applikationshinweise
    Recommended dilution: WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    SPPL2A (Signal Peptide Peptidase-Like 2A (SPPL2A))
    Andere Bezeichnung
    SPPL2A (SPPL2A Produkte)
    Synonyme
    RGD1563001 antikoerper, SPPL2A antikoerper, LOC453430 antikoerper, LOC100231183 antikoerper, IMP3 antikoerper, PSL2 antikoerper, 2010106G01Rik antikoerper, C130089K23Rik antikoerper, signal peptide peptidase-like 2A antikoerper, signal peptide peptidase like 2A antikoerper, Signal peptide peptidase-like 2A antikoerper, Sppl2a antikoerper, SPPL2A antikoerper, sppl2a antikoerper, psl2 antikoerper
    Hintergrund

    Background: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952). Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).

    Aliases: SPPL2A antibody, IMP3 antibody, PSL2 antibody, PSEC0147 antibody, Signal peptide peptidase-like 2A antibody, SPP-like 2A antibody, SPPL2a antibody, EC 3.4.23.- antibody, Intramembrane protease 3 antibody, IMP-3 antibody, Presenilin-like protein 2 antibody

    UniProt
    Q8TCT8
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