SIGLEC7 Antikörper (AA 377-467) (Biotin)

Produktnummer ABIN7169567

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SIGLEC7 in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für SIGLEC7 Antikörper (AA 377-467) (Biotin) (ABIN7169567)

Target: SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIGLEC7 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-SIGLEC7 Antikörper (Biotin)

Bindungsspezifität: AA 377-467

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Sialic acid-binding Ig-like lectin 7 protein (377-467AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SIGLEC7

Target: SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))

Andere Bezeichnung: SIGLEC7

Hintergrund:

Background: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

Aliases: Adhesion inhibitory receptor molecule 1 antibody, Adhesion inhibitory receptor molecule 1, siglec 7 antibody, AIRM 1 antibody, AIRM-1 antibody, AIRM1 antibody, CD328 antibody, CD328 antigen antibody, CDw328 antibody, D siglec antibody, D-siglec antibody, HLDA 8 antibody, p75 antibody, p75/AIRM1 antibody, QA79 antibody, QA79 membrane protein antibody, Sialic acid binding Ig like lectin 7 antibody, Sialic acid binding immunoglobulin like lectin 7 antibody, Sialic acid-binding Ig-like lectin 7 antibody, SIGL7_HUMAN antibody, Siglec-7 antibody, SIGLEC19P antibody, SIGLEC7 antibody, SIGLECP2 antibody

UniProt: Q9Y286