SESN1 Antikörper (AA 224-337) (Biotin)

Produktnummer ABIN7169406

Der Kaninchen Polyklonal Anti-SESN1-Antikörper wurde für ELISA validiert. Er ist geeignet, SESN1 in Proben von Human zu detektieren.

Kurzübersicht für SESN1 Antikörper (AA 224-337) (Biotin) (ABIN7169406)

Target: SESN1 (Sestrin 1 (SESN1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SESN1 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-SESN1 Antikörper (Biotin)

Bindungsspezifität: AA 224-337

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Sestrin-1 protein (224-337AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SESN1

Target: SESN1 (Sestrin 1 (SESN1))

Andere Bezeichnung: SESN1

Hintergrund:

Background: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (By similarity).

Aliases: 1110002G11Rik antibody, AU044290 antibody, MGC118148 antibody, MGC138241 antibody, MGC142129 antibody, OTTMUSP00000022799 antibody, p53 activated gene 26 antibody, p53 regulated PA26 nuclear protein antibody, p53 regulated protein PA26 antibody, p53-regulated protein PA26 antibody, PA26 antibody, RP11-787I22.1 antibody, sesn1 antibody, SESN1_HUMAN antibody, SEST1 antibody, sestrin 1 antibody, Sestrin-1 antibody

UniProt: Q9Y6P5