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WNK4 Antikörper (AA 828-1106) (FITC)

Dieses Anti-WNK4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von WNK4 in . Geeignet für Human.
Produktnummer ABIN7169236

Kurzübersicht für WNK4 Antikörper (AA 828-1106) (FITC) (ABIN7169236)

Target

Alle WNK4 Antikörper anzeigen
WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))

Reaktivität

  • 40
  • 32
  • 27
  • 4
  • 1
Human

Wirt

  • 41
  • 2
Kaninchen

Klonalität

  • 41
  • 2
Polyklonal

Konjugat

  • 13
  • 4
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser WNK4 Antikörper ist konjugiert mit FITC

Applikation

Bitte anfragen
  • Bindungsspezifität

    • 5
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 828-1106

    Kreuzreaktivität

    Human

    Aufreinigung

    >95%, Protein G purified

    Immunogen

    Recombinant Human Serine/threonine-protein kinase WNK4 protein (828-1106AA)

    Isotyp

    IgG
  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))

    Andere Bezeichnung

    WNK4

    Hintergrund

    Background: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).

    Aliases: PHA 2B antibody, PHA2B antibody, PRKWNK 4 antibody, PRKWNK4 antibody, Protein kinase lysine deficient 4 antibody, Protein kinase lysine-deficient 4 antibody, Protein kinase with no lysine 4 antibody, Serine/threonine protein kinase WNK4 antibody, Serine/threonine-protein kinase WNK4 antibody, WNK lysine deficient protein kinase 4 antibody, Wnk4 antibody, WNK4_HUMAN antibody

    UniProt

    Q96J92
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