WNK2 Antikörper (AA 1177-1464)

Produktnummer ABIN7169226

Der Kaninchen Polyklonal Anti-WNK2-Antikörper wurde für ELISA, IHC und IF validiert. Er ist geeignet, WNK2 in Proben von Human zu detektieren.

Kurzübersicht für WNK2 Antikörper (AA 1177-1464) (ABIN7169226)

Target: WNK2 (WNK Lysine Deficient Protein Kinase 2 (WNK2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WNK2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-WNK2 Antikörper

Bindungsspezifität: AA 1177-1464

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Serine/threonine-protein kinase WNK2 protein (1177-1464AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu WNK2

Target: WNK2 (WNK Lysine Deficient Protein Kinase 2 (WNK2))

Andere Bezeichnung: WNK2

Hintergrund:

Background: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.

Aliases: WNK2 antibody, KIAA1760 antibody, PRKWNK2 antibody, SDCCAG43 antibody, P/OKcl.13 antibody, Serine/threonine-protein kinase WNK2 antibody, EC 2.7.11.1 antibody, Antigen NY-CO-43 antibody, Protein kinase lysine-deficient 2 antibody, Protein kinase with no lysine 2 antibody, Serologically defined colon cancer antigen 43 antibody

UniProt: Q9Y3S1

Pathways: Photoperiodism