VRK2 Antikörper (AA 317-472)

Produktnummer ABIN7169218

Produktdetails anti-VRK2 Antikörper

Target: VRK2 (Vaccinia Related Kinase 2 (VRK2))

Bindungsspezifität: AA 317-472

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VRK2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Serine/threonine-protein kinase VRK2 protein (317-472AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:500-1:1000, IF:1:200-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu VRK2

Target: VRK2 (Vaccinia Related Kinase 2 (VRK2))

Andere Bezeichnung: VRK2 (VRK2 Produkte)

Synonyme: 2810003O05Rik antikoerper, AI447698 antikoerper, vaccinia related kinase 2 antikoerper, VRK2 antikoerper, Vrk2 antikoerper

Hintergrund:

Background: Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates \\\'Thr-18\\\' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.

Aliases: 2810003O05Rik antibody, AI447698 antibody, EC 2.7.11.1 antibody, Serine/threonine protein kinase VRK2 antibody, Serine/threonine-protein kinase VRK2 antibody, Vaccinia related kinase 2 antibody, Vaccinia virus B1R related kinase 2 antibody, Vaccinia-related kinase 2 antibody, VRK 2 antibody, VRK2 antibody, VRK2_HUMAN antibody

UniProt: Q86Y07