MASTL Antikörper (AA 612-740)

Produktnummer ABIN7169043

Der Kaninchen Polyklonal Anti-MASTL-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, MASTL in Proben von Human zu detektieren.

Kurzübersicht für MASTL Antikörper (AA 612-740) (ABIN7169043)

Target: MASTL (Microtubule Associated serine/threonine Kinase-Like (MASTL))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MASTL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-MASTL Antikörper

Bindungsspezifität: AA 612-740

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Serine/threonine-protein kinase greatwall protein (612-740AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MASTL

Target: MASTL (Microtubule Associated serine/threonine Kinase-Like (MASTL))

Andere Bezeichnung: MASTL

Hintergrund:

Background: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at \\\'Ser-62\\\' and \\\'Ser-67\\\', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro, however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.

Aliases: 2700091H24Rik antibody, C88295 antibody, FLJ14813 antibody, GREATWALL antibody, Greatwall protein kinase antibody, GW antibody, GWL antibody, GWL_HUMAN antibody, hGWL antibody, MAST-L antibody, Mastl antibody, MGC117975 antibody, Microtubule associated serine/threonine kinase like antibody, Microtubule-associated serine/threonine-protein kinase-like antibody, RP11 85G18.2 antibody, Serine/threonine-protein kinase greatwall antibody, THC2 antibody

UniProt: Q96GX5