SENP6 Antikörper (AA 1-270)

Produktnummer ABIN7168841

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SENP6 in ELISA und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für SENP6 Antikörper (AA 1-270) (ABIN7168841)

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SENP6 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF)

Produktdetails anti-SENP6 Antikörper

Bindungsspezifität: AA 1-270

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Sentrin-specific protease 6 protein (1-270AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SENP6

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Andere Bezeichnung: SENP6

Hintergrund:

Background: Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.

Aliases: 2810017C20Rik antibody, FLJ11355 antibody, FLJ11887 antibody, KIAA0389 antibody, KIAA0797 antibody, SENP 6 antibody, Senp6 antibody, SENP6_HUMAN antibody, Sentrin specific protease 6 antibody, Sentrin-specific protease 6 antibody, Sentrin/SUMO specific protease SENP6 antibody, Sentrin/SUMO-specific protease SENP6 antibody, SSP 1 antibody, SSP1 antibody, SUMO 1 specific protease 1 antibody, SUMO 1 specific protease antibody, SUMO-1-specific protease 1 antibody, SUMO1 specific protease 1 antibody, SUMO1 specific protease antibody, SUMO1/sentrin specific peptidase 6 antibody, SUSP 1 antibody, SUSP1 antibody

UniProt: Q9GZR1