PLA2R1 Antikörper (AA 395-530) (Biotin)

Produktnummer ABIN7168740

Der Kaninchen Polyklonal Anti-PLA2R1-Antikörper wurde für ELISA validiert. Er ist geeignet, PLA2R1 in Proben von Human zu detektieren.

Kurzübersicht für PLA2R1 Antikörper (AA 395-530) (Biotin) (ABIN7168740)

Target: PLA2R1 (phospholipase A2 Receptor 1, 180kDa (PLA2R1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLA2R1 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-PLA2R1 Antikörper (Biotin)

Bindungsspezifität: AA 395-530

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Secretory phospholipase A2 receptor protein (395-530AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PLA2R1

Target: PLA2R1 (phospholipase A2 Receptor 1, 180kDa (PLA2R1))

Andere Bezeichnung: PLA2R1

Hintergrund:

Background: Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.

Aliases: 180 kDa secretory phospholipase A2 receptor antibody, C-type lectin domain family 13 member C antibody, CLEC13C antibody, M type receptor antibody, M-type receptor antibody, Phospholipase A2 receptor 1 antibody, PLA2 R antibody, PLA2-R antibody, PLA2G1R antibody, PLA2IR antibody, PLA2R antibody, PLA2R_HUMAN antibody, PLA2R1 antibody, Soluble PLA2-R antibody, Soluble PLA2R antibody, Soluble secretory phospholipase A2 receptor antibody

UniProt: Q13018

Pathways: Positive Regulation of Response to DNA Damage Stimulus