TARBP2 Antikörper (AA 1-366)

Produktnummer ABIN7168268

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TARBP2 in IHC und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TARBP2 Antikörper (AA 1-366) (ABIN7168268)

Target: TARBP2 (TAR (HIV-1) RNA Binding Protein 2 (TARBP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TARBP2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Produktdetails anti-TARBP2 Antikörper

Bindungsspezifität: AA 1-366

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human RISC-loading complex subunit TARBP2 protein (1-366AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TARBP2

Target: TARBP2 (TAR (HIV-1) RNA Binding Protein 2 (TARBP2))

Andere Bezeichnung: TARBP2

Hintergrund:

Background: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.

Aliases: LOQS antibody, Prbp antibody, RISC loading complex subunit TARBP2 antibody, RISC-loading complex subunit tarbp2 antibody, TAR (HIV 1) RNA binding protein 2 antibody, TAR (HIV) RNA binding protein 2 antibody, TAR (HIV) RNA-binding protein TRBP1 antibody, TAR RNA Binding Protein 2 antibody, TAR RNA-binding protein 2 antibody, tarbp2 antibody, TARBP2 RISC loading complex RNA binding subunit antibody, Trans-activation-responsive RNA-binding protein antibody, TRBP antibody, TRBP1 antibody, TRBP2 antibody, TRBP2_HUMAN antibody

UniProt: Q15633

Pathways: Regulatorische RNA Pathways, Ribonucleoprotein Complex Subunit Organization