ARHGEF18 Antikörper (AA 159-551)

Produktnummer ABIN7167972

Der Kaninchen Polyklonal Anti-ARHGEF18-Antikörper wurde für ELISA, IHC und IF validiert. Er ist geeignet, ARHGEF18 in Proben von Human zu detektieren.

Kurzübersicht für ARHGEF18 Antikörper (AA 159-551) (ABIN7167972)

Target: ARHGEF18 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 18 (ARHGEF18))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARHGEF18 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-ARHGEF18 Antikörper

Bindungsspezifität: AA 159-551

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Rho guanine nucleotide exchange factor 18 protein (159-551AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ARHGEF18

Target: ARHGEF18 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 18 (ARHGEF18))

Andere Bezeichnung: ARHGEF18

Hintergrund:

Background: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950).

Aliases: 114 kDa Rho specific guanine nucleotide exchange factor antibody, 114 kDa Rho-specific guanine nucleotide exchange factor antibody, ARHGEF 18 antibody, Arhgef18 antibody, ARHGI_HUMAN antibody, KIAA0521 antibody, MGC15913 antibody, p114 Rho GEF antibody, p114-Rho-GEF antibody, p114RhoGEF antibody, Rho guanine nucleotide exchange factor 18 antibody, Rho specific guanine nucleotide exchange factor p114 antibody, Rho/Rac guanine nucleotide exchange factor (GEF) 18 antibody, Rho/Rac guanine nucleotide exchange factor 18 antibody, SA RhoGEF antibody, SA-RhoGEF antibody, Septin associated RhoGEF antibody, Septin-associated RhoGEF antibody

UniProt: Q6ZSZ5

Pathways: Neurotrophin Signalübertragung