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RGMA Antikörper (AA 153-408)

This anti-RGMA antibody (ABIN7167709) is a Rabbit Polyclonal antibody detecting RGMA in WB, ELISA, IHC. Suitable for Human.
Produktnummer ABIN7167709

Kurzübersicht für RGMA Antikörper (AA 153-408) (ABIN7167709)

Target

Alle RGMA Antikörper anzeigen
RGMA (RGM Domain Family, Member A (RGMA))

Reaktivität

  • 23
  • 7
  • 4
  • 1
  • 1
Human

Wirt

  • 24
  • 1
Kaninchen

Klonalität

  • 21
  • 4
Polyklonal

Konjugat

  • 14
  • 3
  • 3
  • 2
  • 2
  • 1
Dieser RGMA Antikörper ist unkonjugiert

Applikation

  • 21
  • 18
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 10
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 153-408

    Kreuzreaktivität

    Human, Maus

    Aufreinigung

    >95%, Protein G purified

    Immunogen

    Recombinant Human Repulsive guidance molecule A protein (153-408AA)

    Isotyp

    IgG
  • Applikationshinweise

    Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    RGMA (RGM Domain Family, Member A (RGMA))

    Andere Bezeichnung

    RGMA

    Hintergrund

    Background: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

    Aliases: Repulsive guidance molecule A antibody, RGM antibody, RGM domain family member A antibody, RGMA antibody, RGMA_HUMAN antibody

    UniProt

    Q96B86

    Pathways

    Tube Formation
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