RGMA Antikörper (AA 153-408)

Produktnummer ABIN7167709

Dieses Anti-RGMA-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von RGMA in WB, ELISA und IHC. Geeignet für Human.

Kurzübersicht für RGMA Antikörper (AA 153-408) (ABIN7167709)

Target: RGMA (RGM Domain Family, Member A (RGMA))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RGMA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-RGMA Antikörper

Bindungsspezifität: AA 153-408

Kreuzreaktivität: Human, Maus

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Repulsive guidance molecule A protein (153-408AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RGMA

Target: RGMA (RGM Domain Family, Member A (RGMA))

Andere Bezeichnung: RGMA

Hintergrund:

Background: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Aliases: Repulsive guidance molecule A antibody, RGM antibody, RGM domain family member A antibody, RGMA antibody, RGMA_HUMAN antibody

UniProt: Q96B86

Pathways: Tube Formation