PTPRJ Antikörper (AA 140-370)

Produktnummer ABIN7167504

Der Kaninchen Polyklonal Anti-PTPRJ-Antikörper wurde für IHC und ELISA validiert. Er ist geeignet, PTPRJ in Proben von Human zu detektieren.

Kurzübersicht für PTPRJ Antikörper (AA 140-370) (ABIN7167504)

Target: PTPRJ (Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTPRJ Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Produktdetails anti-PTPRJ Antikörper

Bindungsspezifität: AA 140-370

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Receptor-type tyrosine-protein phosphatase eta protein (140-370AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PTPRJ

Target: PTPRJ (Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ))

Andere Bezeichnung: PTPRJ

Hintergrund:

Background: Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration, through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation, through KDR dephosphorylation. Negative regulator of EGFR signaling pathway, through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.

Aliases: CD 148 antibody, CD148 antibody, CD148 antigen antibody, Density enhanced phosphatase 1 antibody, Density-enhanced phosphatase 1 antibody, DEP 1 antibody, DEP-1 antibody, HPTP eta antibody, HPTPeta antibody, Human density enhanced phosphatase 1 antibody, Protein tyrosine phosphatase eta antibody, Protein tyrosine phosphatase receptor type J antibody, Protein tyrosine phosphatase receptor type J polypeptide antibody, Protein-tyrosine phosphatase eta antibody, Protein-tyrosine phosphatase receptor type J antibody, PTPJ antibody, Ptprj antibody, PTPRJ_HUMAN antibody, R PTP Eta antibody, R-PTP-eta antibody, R-PTP-J antibody, Receptor type tyrosine protein phosphatase eta antibody, Receptor-type tyrosine-protein phosphatase eta antibody, SCC 1 antibody, SCC1 antibody, susceptibility to colon cancer 1, mouse, homolog of antibody

UniProt: Q12913

Pathways: EGFR Signaling Pathway, Platelet-derived growth Factor Receptor Signaling