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RAB7A Antikörper (AA 110-177)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch RAB7A in ELISA, IHC und IF. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN7167377

Kurzübersicht für RAB7A Antikörper (AA 110-177) (ABIN7167377)

Target

Alle RAB7A Antikörper anzeigen
RAB7A (RAB7A, Member RAS Oncogene Family (RAB7A))

Reaktivität

  • 55
  • 28
  • 26
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 52
  • 2
  • 1
  • 1
Kaninchen

Klonalität

  • 43
  • 14
Polyklonal

Konjugat

  • 33
  • 4
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Dieser RAB7A Antikörper ist unkonjugiert

Applikation

  • 38
  • 20
  • 13
  • 9
  • 8
  • 7
  • 4
  • 2
  • 1
  • 1
ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
  • Bindungsspezifität

    • 8
    • 8
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 110-177

    Kreuzreaktivität

    Human

    Aufreinigung

    >95%, Protein G purified

    Immunogen

    Recombinant Human Ras-related protein Rab-7a protein (110-177AA)

    Isotyp

    IgG
  • Applikationshinweise

    Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    RAB7A (RAB7A, Member RAS Oncogene Family (RAB7A))

    Andere Bezeichnung

    RAB7A

    Hintergrund

    Background: Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

    Aliases: CMT2B antibody, PRO2706 antibody, PSN antibody, RAB7, member RAS oncogene family antibody, RAB7A antibody, RAB7A, member RAS oncogene family antibody, RAB7A_HUMAN antibody, Ras associated protein RAB7 antibody, Ras related protein Rab7 antibody, Ras related protein Rab7a antibody, Ras-related protein Rab-7a antibody

    UniProt

    P51149

    Pathways

    EGFR Signaling Pathway, Maintenance of Protein Location, SARS-CoV-2 Protein Interaktom
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