RASGRP1 Antikörper (AA 594-716)

Produktnummer ABIN7167163

Dieses Anti-RASGRP1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von RASGRP1 in ELISA und IF. Geeignet für Human.

Kurzübersicht für RASGRP1 Antikörper (AA 594-716) (ABIN7167163)

Target: RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RASGRP1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF)

Produktdetails anti-RASGRP1 Antikörper

Bindungsspezifität: AA 594-716

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human RAS guanyl-releasing protein 1 protein (594-716AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RASGRP1

Target: RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))

Andere Bezeichnung: RASGRP1

Hintergrund:

Background: Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types (PubMed:12845332).

Aliases: RASGRP1 antibody, RASGRPRAS guanyl-releasing protein 1 antibody, Calcium and DAG-regulated guanine nucleotide exchange factor II antibody, CalDAG-GEFII antibody, Ras guanyl-releasing protein antibody

UniProt: O95267

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung