S100A12 Antikörper (AA 2-91)

Produktnummer ABIN7166043

Der Kaninchen Polyklonal Anti-S100A12-Antikörper wurde für IHC und ELISA validiert. Er ist geeignet, S100A12 in Proben von Human zu detektieren.

Kurzübersicht für S100A12 Antikörper (AA 2-91) (ABIN7166043)

Target: S100A12 (S100 Calcium Binding Protein A12 (S100A12))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser S100A12 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Produktdetails anti-S100A12 Antikörper

Bindungsspezifität: AA 2-91

Verwendungszweck: S100A12 Antibody

Aufreinigung: Antigen Affinity purified & Affinity purified

Reinheit: >95 %

Immunogen: Recombinant Human Protein S100-A12 protein (2-91AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu S100A12

Target: S100A12 (S100 Calcium Binding Protein A12 (S100A12))

Andere Bezeichnung: S100A12

Hintergrund:

Background: S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases, MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.

Aliases: CAAF1 antibody, CAGC antibody, Calcitermin antibody, Calcium-binding protein in amniotic fluid 1 antibody, Calgranulin C antibody, Calgranulin-C antibody, Calgranulin-related protein antibody, CGRP antibody, EN RAGE antibody, EN-RAGE antibody, ENRAGE antibody, Extracellular newly identified RAGE-binding protein antibody, migration inhibitory factor-related protein 6 antibody, MRP6 antibody, Neutrophil S100 protein antibody, p6 antibody, Protein S100 A12 antibody, S100 calcium binding protein A12 antibody, S100 calcium-binding protein A12 (calgranulin C) antibody, S100 calcium-binding protein A12 antibody, S100A12 antibody, S10AC_HUMAN antibody

UniProt: P80511

Pathways: Toll-Like Receptors Cascades, S100 Proteine