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MAGOH Antikörper (AA 1-146)

MAGOH Reaktivität: Human WB, ELISA, IHC, IP Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7165791
  • Target Alle MAGOH Antikörper anzeigen
    MAGOH (Mago-Nashi Homolog (MAGOH))
    Bindungsspezifität
    • 15
    • 8
    • 7
    • 6
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-146
    Reaktivität
    • 27
    • 20
    • 19
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 36
    • 5
    • 1
    Kaninchen
    Klonalität
    • 38
    • 4
    Polyklonal
    Konjugat
    • 18
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MAGOH Antikörper ist unkonjugiert
    Applikation
    • 25
    • 22
    • 15
    • 14
    • 14
    • 5
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
    Kreuzreaktivität
    Human, Maus
    Aufreinigung
    Antigen Affinity Purified
    Immunogen
    Recombinant Human Protein mago nashi homolog protein (1-146AA)
    Isotyp
    IgG
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  • Applikationshinweise
    Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    MAGOH (Mago-Nashi Homolog (MAGOH))
    Andere Bezeichnung
    MAGOH (MAGOH Produkte)
    Synonyme
    MAGOH1 antikoerper, MAGOHA antikoerper, Mago-m antikoerper, Mos2 antikoerper, MAGOH antikoerper, zgc:112220 antikoerper, mago antikoerper, xl-mago antikoerper, CG9401 antikoerper, Dm MGN antikoerper, DmMago antikoerper, Dmel\CG9401 antikoerper, MGN antikoerper, Mago antikoerper, Magoh antikoerper, l(2)57Ca antikoerper, mgn antikoerper, magoh antikoerper, mago homolog, exon junction complex core component antikoerper, protein mago nashi homolog antikoerper, mago homolog, exon junction complex core component L homeolog antikoerper, mago nashi antikoerper, MAGOH antikoerper, Magoh antikoerper, LOC736868 antikoerper, magoh antikoerper, magoh.L antikoerper, mago antikoerper, LOC106584057 antikoerper
    Hintergrund

    Background: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes), specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S), the function is different from the established EJC assembly.

    Aliases: Mago nashi homolog proliferation associated (Drosophila) antibody, Mago nashi protein homolog antibody, magoh antibody, MAGOHA antibody, MGN_HUMAN antibody, Protein mago nashi homolog antibody

    UniProt
    P61326
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